Quantifiability of semi-quantitative GC/MS
Gas chromatography coupled with mass spectrometry (GC/MS) is a widely used method for analyzing chemical substances. Especially in the context of non-target screening, as required by ISO 10993-18 for the chemical characterization of medical devices, semi-quantitative GC/MS plays a decisive role.
Semiquantitative analyses do not provide exact concentration data, but rather estimate the quantity ratios of the detected substances. This process is based on the comparison of the signal intensities of the unknown substances with those of standard substances. The method proves to be particularly useful when it comes to identifying a large number of substances in a sample and determining their relative amounts.
In our article, we would like to explain helpful and essential aspects of semi-quantitative GC/MS in conjunction with chemical characterization according to ISO 10993-18.
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