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Smith & Nephew GmbH

Manufacturer & Sales

Smith & Nephew GmbHREGENETS - Bioinductive Implant - Sports Medicine

REGENETS - Bioinductive Implant - Sports Medicine

A new avenue for treating rotator cuff lesions

Rotator cuff disease is a significant and costly problem, 2,4 causing continuous pain and limiting patient mobility. 5 Because of their progressive nature, small cracks tend to get larger and more severe over time, ultimately requiring surgery. 1.3

  • Up to 80% of the partial cracks enlarge within two years. 6th
  • If left untreated, rotator cuff tendinosis can progress to partial or complete rupture. 7th
  • Larger cracks that require surgery tend to re-rupture in over 40% of cases. 8.10

You can now biologically interrupt the progression of rotator cuff disease. The REGENETEN bioinductive implant stimulates the body's natural healing response to encourage new tendon growth and disrupt progression. 1.2

It is obtained from highly purified bovine Achilles tendons and creates a healing environment. 1.2

 

Better healing in a biological way

  • The protected, highly porous implant enables the formation of new tendon-like tissue 1,2
  • New tissue lowers the peak load at the tear site 11
  • Gradually reabsorbed over 6 months, leaving a layer of new tendon-like tissue for biological augmentation of the native tendon 12
 
- Induction of new tendon-like tissue in all patients (N = 33)
- Mean increase in tendon thickness of 2.2mm (P <0.0001) after 3 months
- Potential reduction of new cracks 13

- No foreign body / inflammation reaction

- No implant-related complications

-High patient satisfaction (94%) after 1 year
- Rapid recovery: average wearing time of the arm sling 23 days - Significantly improved ASES
- Pain score after 1 year (P <0.0001) ≠

 

Natural progression of rotator cuff disease

 

Results from a prospective multicenter study among patients with partial tears. The patients suffered from chronic, degenerative, moderate (n = 12) or high-grade (n = 21) partial tears of the supraspinatus tendon. The REGENETEN bioinductive implant was implanted without repair following arthroscopic subacromial decompression. The clinical outcome was assessed preoperatively as well as 3 and 12 months postoperatively using the American Shoulder and Elbow Surgeons (ASES) and Constant-Murley scores. Postoperative healing and tendon thickness were assessed using MRI. ≠ The ASES pain score decreased from 4.2 ± 0.4 standard error of the mean (SEM) in the initial state to 0.6 ± 0.2 (SEM) after 1 year.

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